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KMID : 0882419930440050627
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Korean Journal of Medicine
1993 Volume.44 No. 5 p.627 ~ p.635
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Effect of Radioiodine Treatment on Serum Soluble interleukin-2 Receptor (IL-2R) Level in Patients with Graves' Disease
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여준기
박정모/조성래/남복현/한승범/박근용/이인규/안성훈/이재태
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Abstract
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ackground : Graves' disease is associated with the presence of autoantibodies, alterations
of T cell subsets, and abnormalities of T cell function. Activated T cells and the level of
serum soluble IL-2R, which was released from activeated T cells, were increased in untreated
hyperthyroid Graves' disease compared to those in normal individuals and decreased with
radioiodine and/or antithyroid drug treatment.
Thus, soluble IL-2R can be utilized as immunological marker for activity of Graves'
disease and activation of T cells.
Methods ; We studied 35 patients with hyperthyroid Graves' disease and administered
radioiodine and/or antithyroid drugs. We measured serum soluble IL-2R by enzyme-linked
immounosorbent assay, before and after treatment, respectively.
Results ; Serum soluble IL-2R levels showed statistically significant decrement in
accordance with the decline of thyroid hormone levels during radioiodine treatment.
There were statistically significant correlation between soluble IL-2R and thyroid hormone
before and after treatment.
Conclusions; Thus, in vivo measurement of serum soluble IL-2R released from activated T
cells is a useful immunological marker of disease activity in hyperthyroid Graves' disease.
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KEYWORD
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